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Questions Available: 68
Year: 2022
Topic: Molecular Basis of Inheritance
1.
Transposons can be used during which one of the following?
(1).
Polymerase chain reaction
(2).
Gene silencing
(3).
Autoradiography
(4).
Gene sequencing

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Solution
Year: 2022
Topic: Molecular Basis of Inheritance
2.
DNA polymorphism forms the basis of:
(1).
Genetic mapping
(2).
DNA finger printing
(3).
Both genetic mapping and DNA fingerprinting
(4).
Translation

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Solution
Year: 2021
Topic: Molecular Basis of Inheritance
3.
Complete the flow chart on central dogma.
(1).
(a)-Replication; (b)-Transcription; (c)-Transduction; (d)-Protein
(2).
(a)-Translation; (b)-Replication; (c)-Transcription; (d)-Transduction
(3).
(a)-Replication; (b)-Transcription; (c)-Translation; (d).Protein
(4).
(a)-Transduction; (b)-Translation; (c)-Replication; (d)-Protein

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Year: 2021
Topic: Molecular Basis of Inheritance
4.
If Adenine makes 30% of the DNA molecule, what will be the percentage of Thymine, Guanine and Cytosine in it?
(1).
T: 20; G: 30; C: 20
(2).
T: 20; G: 20: C: 30
(3).
T:30; G: 20; C: 20
(4).
T: 20: G: 25; C: 25

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Solution
Year: 2020
Topic: Molecular Basis of Inheritance
5.
If the distance between two consecutive base pairs is 0.34 nm and the total number of base pairs of a DNA double helix in a typical mammalian cell is 6.6 x 109 bp, then the length of the DNA is approximately:
(1).
2.5 meters
(2).
2.2 meters
(3).
2.7 meters
(4).
2.0 meters

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Solution
Year: 2020
Topic: Molecular Basis of Inheritance
6.
Name the enzyme that facilitates opening of DNA helix during transcription.
(1).
DNA helicase
(2).
DNA polymerase
(3).
RNA polymerase
(4).
DNA ligase

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Solution
Year: 2019
Topic: Molecular Basis of Inheritance
7.
A gene locus has two alleles A, a. If the frequency of dominant allele A is 0.4, then what will be the frequency of homozygous dominant, heterozygous and homozygous recessive individuals in the population ?
(1).
0.16 (AA); 0.24 (Aa); 0.36 (aa)
(2).
0.16 (AA); 0.48 (Aa); 0.36 (aa)
(3).
0.16 (AA); 0.36 (Aa); 0.48 (aa)
(4).
0.36 (AA); 0.48 (Aa); 0.16 (aa)

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Solution
Year: 2019
Topic: Molecular Basis of Inheritance
8.
Under which of the following conditions will there be no change in the reading frame of following mRNA ? 5' AACAGCGGUGCUAUU 3'
(1).
Deletion of G from 5th position
(2).
Insertion of A and G at 4th and 5th positions respectively
(3).
Deletion of GGU from 7th, 8th and 9th positions
(4).
Insertion of G at 5th position

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Year: 2018
Topic: Molecular Basis of Inheritance
9.
Select the correct match
(1).
Francois Jacob and Jacques Monod - lac operon
(2).
Matthew Meselson and F. Stahl - Pisum sativum
(3).
Alfred Hershey and Martha Chase - TMV
(4).
Alec Jeffreys - Streptococcus pneumoniae

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Year: 2018
Topic: Molecular Basis of Inheritance
10.
All of the following are part of an operon except
(1).
a promoter.
(2).
an enhancer.
(3).
structural genes.
(4).
an operator.

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Year: 2017
Topic: Molecular Basis of Inheritance
11.
The final proof for DNA as the genetic material came from the experiments of
(1).
Hargobind Khorana
(2).
Griffith
(3).
Hershey and Chase
(4).
Avery, Mcleod and McCarty

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Year: 2017
Topic: Molecular Basis of Inheritance
12.
During DNA replication, Okazaki fragments are used to elongate
(1).
the lagging strand away from the replication fork.
(2).
the leading strand towards the replication fork.
(3).
the lagging strand towards the replication fork.
(4).
the leading strand away from the replication fork.

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Year: 2017
Topic: Molecular Basis of Inheritance
13.
A disease caused by an autosomal primary non- disjunction is
(1).
sickle cell anemia.
(2).
down's syndrome.
(3).
klinefelter's syndrome.
(4).
turner's syndrome.

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Year: 2025
Topic: Molecular Basis of Inheritance
14.
Name the class of enzyme that usually catalyze the following reaction :
S - G + S# → S + S# - G
Where, G → a group other than hydrogen
S → a substrate
S# → another substrate
(1).
Ligase
(2).
Hydrolase
(3).
Lyase
(4).
Transferase

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Year: 2025
Topic: Molecular Basis of Inheritance
15.
Given below are two statements
Statement I : In the RNA world, RNA is considered the first genetic material evolved to carry out essential life processes. RNA acts as a genetic material and also as a catalyst for some important biochemical reactions in living systems. Being reactive, RNA is unstable.
Statement II: DNA evolved from RNA and is a more stable genetic material. Its double helical strands being complementary, resist changes by evolving repairing mechanism.
In the light of the above statements, choose the most appropriate answer from the options given below :
(1).
Statement I is incorrect but statement II is correct
(2).
Both statement I and statement II are correct
(3).
Both statemént I and statement II are incorrect
(4).
Statement I is correct but statement II is incorrect

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Solution
Year: 2025
Topic: Molecular Basis of Inheritance
16.
Given below are two statements
Statement I : Transfer RNAs and ribosomal RNA do not interact with mRNA.
Statement II : RNA interference (RNAi) takes place in all eukaryotic organisms as a method of cellular defence,
In the light of the above statements, choose the most appropriate answer from the options given bclow:
(1).
Statement I is incorrect but Statement II is correct
(2).
Both Statement I and Statement II are correct
(3).
Both Statement I and Statement II are incorrect
(4).
Statement I is correct but Statement II is incorrect

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Year: 2025
Topic: Molecular Basis of Inheritance
17.
Which of the following are the post-transcriptional events in an eukaryotic cell?
A. Transport of pre-mRNA to cytoplasm prior to splicing.
B. Removal of introns and joining of exons.
C. Addition of methyl group at 5 end of hnRNA.
D. Addition of adenine residues at 3 end of hnRNA.
E. Base pairing of two complementary RNAs.
Choose the correct answer from the options given below :
(1).
C, D, E only
(2).
A, B, C only
(3).
B, C, D only
(4).
B, C, E only

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Year: 2025
Topic: Molecular Basis of Inheritance
18.
Match List - I with List - II

Choose the correet answer from the optionsgiven below :
(1).
A-III, B-II, C-IV, D-I
(2).
A-II, B-IV, C-I, D-III
(3).
A-IV, B-II, C-I, D-III
(4).
A-IV, B-III, C-I, D-II

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Year: 2025
Topic: Molecular Basis of Inheritance
19.
Which chromosome in the human genome has the highest number of genes?
(1).
Chromosome 10
(2).
Chromosome X
(3).
ChromosomeY
(4).
Chromosome I

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Year: 2025
Topic: Molecular Basis of Inheritance
20.
Who proposed that the genetic code for amino acids should be made up of three nucleotides?
(1).
Franklin Stahl,
(2).
George Gamow
(3).
Francis Crick
(4).
Jacque Monod

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Year: 2025
Topic: Molecular Basis of Inheritance
21.
Histones are enriched with -
(1).
Phenylalanine & Arginine
(2).
Lysine & Arginine
(3).
Leucine & Lysine
(4).
Phenylalanine & Leucin

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Year: 2025
Topic: Molecular Basis of Inheritance
22.
Which factor is important for termination of transcription?
(1).
\(\gamma\) (gamma)
(2).
\(\alpha\) (alpha)
(3).
\(\sigma\) (sigma)
(4).
\(\rho\) (rho)

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Year: 2024
Topic: Molecular Basis of Inheritance
23.
A transcription unit in DNA is defined primarily by the three regions in DNA and these are with respect to upstream and downstream end;
(1).
Inducer, Repressor, Structural gene
(2).
Promotor, Structural gene, Terminator
(3).
Repressor, Operator gene, Structural gene
(4).
Structural gene, Transposons, Operator gene

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Solution
Year: 2024
Topic: Molecular Basis of Inheritance
24.
The lactose present in the growth medium of bacteria is transported to the cell by the action of
(1).
Permease
(2).
Polymerase
(3).
Beta-galactosidase
(4).
Acetylase

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Solution
Year: 2024
Topic: Molecular Basis of Inheritance
25.
Which of the following statement is correct regarding the process of replication in E.coli?
(1).
The DNA dependent DNA polymerase catalyses polymerization in 5’ \(\rightarrow\) 3’ as well as 3’ \(\rightarrow\) 5’ direction.
(2).
The DNA dependent DNA polymerase catalyses polymerization in 5’ \(\rightarrow\) 3’ direction.
(3).
The DNA dependent DNA polymerase catalyses polymerization in one direction that is 3’ \(\rightarrow\) 5’.
(4).
The DNA dependent RNA polymerase catalyses polymerization in one direction, that is 5’ \(\rightarrow\) 3’.

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Year: 2024
Topic: Molecular Basis of Inheritance
26.
Match List I with List II:
Choose the correct answer from the options given below:
(1).
A-II, B-III, C-IV, D-I
(2).
A-IV, B-I, C-II, D-III
(3).
A-III, B-II, C-I, D-IV
(4).
A-III, B-IV, C-I, D-II

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Year: 2024
Topic: Molecular Basis of Inheritance
27.
Which one is the correct product of DNA dependent RNA polymerase to the given template?
3'TACATGGCAAATATCCATTCA5 '
(1).
5'AUGUACCGUUUAUAGGGAAGU3 '
(2).
5'ATGTACCGTTTATAGGTAAGT3 '
(3).
5 ' AUGUACCGUUUAUAGGUAAGU3 '
(4).
5'AUGUAAAGUUUAUAGGUAAGU3 '

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Solution
Year: 2024
Topic: Molecular Basis of Inheritance
28.
Match List I with List II:

Choose the correct answer from the options given below:
(1).
A-III, B-IV, C-I, D-II
(2).
A-IV, B-III, C-I, D-II
(3).
A-II, B-IV, C-I, D-III
(4).
A-III, B-II, C-IV, D-I

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Year: 2023
Topic: Molecular Basis of Inheritance
29.
Unequivocal proof that DNA is the genetic material was first proposed by
(1).
Alfred Hershey and Martha Chase
(2).
Avery, Macleoid and MeCarthy
(3).
Wilkins and Franklin
(4).
Frederick Gritith

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Year: 2023
Topic: Molecular Basis of Inheritance
30.
What is the role of RNA polymerase III in the process of transcription in Eukaryotes ?
(1).
Transcription of tRNA, 5 srRNA and snRNA
(2).
Transcription of precursor of mRNA
(3).
Transcription of only snRNAs
(4).
Transcription of rRNAs (28S, 18S and 5.8S)

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Year: 2023
Topic: Molecular Basis of Inheritance
31.
Expressed Sequence Tags (ESTs) refers to:
(1).
All genes that are expressed as proteins.
(2).
All genes whether expressed or unexpressed.
(3).
Certain important expressed genes.
(4).
All genes that are expressed as RNA.

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Year: 2023
Topic: Molecular Basis of Inheritance
32.
Match List I with List II.

Choose the correct answer from the options given below :
(1).
A-II, B-III, C-IV, D-I
(2).
A-III, B-IV, C-I, D-II
(3).
A-III, B-I, C-IV,D-II
(4).
A-II, B-I, C-IV, D-III

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Year: 2023
Topic: Molecular Basis of Inheritance
33.
Given below are two statements :
Statemnent I : RNA mutates at a faster rate.
Statement II : Viruses having RNA genome and shorter life span mutate and evolve faster.
In the light of the above statements, choose the correct answer from the options given below:
(1).
Both Statement I and Statement II are false.
(2).
Statement I is true but Statement II is false.
(3).
Statement I false but Statement II is true.
(4).
Both Statement I and Statement II are true.

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Year: 2023
Topic: Molecular Basis of Inheritance
34.
Which one of the following is the sequence on corresponding coding strand, if the sequence on mRNA formed is as follows:
5' AUCGAUCGAUCGAUCGAUCG AUCG AUCG 3'?
(1).
3' UAGCUAGCUAGCUAGCUA GCUAGCỦAGC 5'
(2).
5' ATCGATCGATCGATCGATCG ATCGATCG 3'
(3).
3' ATCGATCGATCGATCGATCG ATCGATCG 5'
(4).
5' UAGCUAGCUAGCUAGCUAGC UAGC UAGC 3'

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Year: 2022
Topic: Molecular Basis of Inheritance
35.
If a geneticist uses the blind approach for sequencing the whole genome of an organism, followed by assignment of functions to different segment, the methodology adopted by him is called as:
(1).
Sequence annotation
(2).
Gene mapping
(3).
Expressed sequence tags
(4).
Bioinformatics

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Year: 2022
Topic: Molecular Basis of Inheritance
36.
In an E. coli strain the i gene gets mutated and its product can not bind the inducer molecule. If the growth medium is provided with lactose, what will be the outcome?
(1).
Only z gene will get transcribed
(2).
z, y, a genes will be transcribed
(3).
Z, y, a genes will not be translated
(4).
RNA polymerase will bind the promoter region

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Year: 2022
Topic: Molecular Basis of Inheritance
37.
If the length of a DNA molecule is 1.1 metres, what will be the approximate number of base pairs?
(1).
3.3 × 109 bp
(2).
6.6 x 109 bp
(3).
3.3 x 106 bp
(4).
6.6 x 106 bp

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Year: 2022
Topic: Molecular Basis of Inheritance
38.
Ten E. coli cells with 15N- dsDNA are incubated in a medium containing 14N nucleotides. After 60 minutes, how many E. coli cells will have DNA totally free from 15N?
(1).
20 cells
(2).
40 cells
(3).
60 cells
(4).
80 cells

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Year: 2022
Topic: Molecular Basis of Inheritance
39.
The process of translation of mRNA to proteins begins as soon as:
(1).
The small subunit of ribosome encounters mRNA
(2).
The larger subunit of ribosome encounters mRNA
(3).
Both the subunits join together to bind with mRNA
(4).
The tRNA is activated and the larger subunit of ribosome encounters mRNA

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Year: 2022
Topic: Molecular Basis of Inheritance
40.
Read the following statements and choose the set of correct statements:
(a) Euchromatin is loosely packed chromatin.
(b) Heterochromatin is transcriptionally active.
(c) Histone octamer is wrapped by negatively charged DNA in nucleosome.
(d) Histones are rich in lysine and arginine.
(e) Atypical nucleosome contains 400 bp of DNA helix.
Choose the correct answer from the options given below:
(1).
(b), (d), (e) Only
(2).
(a), (c), (d) Only
(3).
(b), (e) Only
(4).
(a), (c), (e) Only

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Year: 2021
Topic: Molecular Basis of Inheritance
41.
Which one of the following statements about Histones is wrong?
(1).
Histones are organized to form a unit of 8 molecules.
(2).
The pH of histones is slightly acidic.
(3).
Histones are rich in amino acids - Lysine and Arginine.
(4).
Histones carry positive charge in the side chain.

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Year: 2021
Topic: Molecular Basis of Inheritance
42.
Statement I: The codon 'AUG' codes for methionine and phenylalanine.
Statement II: 'AAA' and 'AAG both codons code for the amino acid lysine.
In the light of the above statements, choose the correct answer from the options given below.
(1).
Both Statement I and Statement II are true
(2).
Both Statement I and Statement II are false
(3).
Statement I is correct but Statement II is false
(4).
Statement I is incorrect but Statement II is true

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Year: 2021
Topic: Molecular Basis of Inheritance
43.
Identify the correct statement.
(1).
In capping, methyl guanosine triphosphate is added to the 3` end of hnRNA.
(2).
RNA polymerase binds with Rho factor to terminate the process of transcription in bacteria.
(3).
The coding strand in a transcription unit is copied to an mRNA.
(4).
Split gene arrangement is characteristic of prokaryotes.

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Year: 2021
Topic: Molecular Basis of Inheritance
44.
What is the role of RNA polymerase III in the process of transcription in eukaryotes?
(1).
Transcribes rRNAs (28 S,18 S and 5.8 S)
(2).
Transcribes tRNA, 5srRNA and snRNA
(3).
Transcribes precursor of mRNA
(4).
Transcribes only snRNAs

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Year: 2021
Topic: Molecular Basis of Inheritance
45.
Which of the following RNAs is not required for the synthesis of protein?
(1).
mRNA
(2).
tRNA
(3).
rRNA
(4).
siRNA

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Solution
Year: 2021
Topic: Molecular Basis of Inheritance
46.
Which is the "Only enzyme" that has "Capability" to catalyse Initiation, Elongation and Termination in the process of transcription in prokaryotes?
(1).
DNA dependent DNA polymerase
(2).
DNA dependent RNA polymerase
(3).
DNA Ligase
(4).
DNAse

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Year: 2020
Topic: Molecular Basis of Inheritance
47.
The first phase of translation is:
(1).
Recognition of DNA molecule
(2).
Aminoacylation of tRNA
(3).
Recognition of an anti-codon
(4).
Binding of mRNA to ribosome

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Solution
Year: 2020
Topic: Molecular Basis of Inheritance
48.
Which of the following statements is not correct?
(1).
The proinsulin has an extra peptide called C- peptide.
(2).
The functional insulin has A and B chains linked together by hydrogen bonds.
(3).
Genetically engineered insulin is produced in E-Coli.
(4).
In man insulin is synthesised as a proinsulin.

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Year: 2020
Topic: Molecular Basis of Inheritance
49.
The sequence that controls the copy number of the linked DNA in the vector, is termed:
(1).
Ori site
(2).
Palindromic sequence
(3).
Recognition site
(4).
Selectable marker

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Solution
Year: 2020
Topic: Molecular Basis of Inheritance
50.
Select the correct match.
(1).
Phenylketonuria - Autosomal dominant trait
(2).
Sickle cell anaemia - Autosomal recessive trait, chromosome-11
(3).
Thalassemia - X-linked
(4).
Haemophilia - Y-linked

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Year: 2020
Topic: Molecular Basis of Inheritance
51.
Which of the following statements is correct ?
(1).
Adenine pairs with thymine through one H-bond.
(2).
Adenine pairs with thymine through three H-bonds.
(3).
Adenine does not pair with thymine.
(4).
Adenine pairs with thymine through two H-bonds.

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Year: 2020
Topic: Molecular Basis of Inheritance
52.
Choose the correct pair from the following: Break the DNA into
(1).
Polymerases fragments Separate the two strands of
(2).
Nucleases DNA
(3).
Exonucleases Make cuts at specific positions within DNA - Join the two DNA molecules
(4).
Ligases

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Year: 2019
Topic: Molecular Basis of Inheritance
53.
Select the incorrect statement :
(1).
In male grasshoppers, 50% of sperms have no sex-chromosome.
(2).
In domesticated fowls, sex of progeny depends on the type of sperm rather than egg.
(3).
Human males have one of their sex-chromosome much shorter than the other.
(4).
Male fruit fly is heterogametic.

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Year: 2019
Topic: Molecular Basis of Inheritance
54.
Expressed Sequence Tags (ESTs) refers to
(1).
polypeptide expression.
(2).
DNA polymorphism.
(3).
Novel DNA sequences.
(4).
genes expressed as RNA

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Solution
Year: 2019
Topic: Molecular Basis of Inheritance
55.
Match the following genes of the Lac operon with their respective products

Select the correct option from the following
(1).
(a) - (iii), (b) - (i), (c) - (ii), (d) - (iv)
(2).
(a) - (iii), (b) - (i), (c) - (iv), (d) - (ii)
(3).
(a) - (iii), (b) - (iv), (c) - (i), (d) - (ii)
(4).
(a) - (i), (b) - (iii), (c) - (ii), (d) - (iv)

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Year: 2019
Topic: Molecular Basis of Inheritance
56.
Which of the following features of genetic code does allow bacteria to produce human insulin by recombinant DNA technology ?
(1).
Genetic code is redundant
(2).
Genetic code is nearly universal
(3).
Genetic code is specific
(4).
Genetic code is not ambiguous

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Solution
Year: 2019
Topic: Molecular Basis of Inheritance
57.
Purines found in the DNA and RNA are
(1).
adenine and guanine.
(2).
guanine and cytosine.
(3).
cytosine and thymine.
(4).
adenine and thymine.

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Year: 2018
Topic: Molecular Basis of Inheritance
58.
The experimental proof for semi-conservative replication of DNA was first shown in a
(1).
virus.
(2).
plant.
(3).
bacterium.
(4).
fungus.

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Year: 2018
Topic: Molecular Basis of Inheritance
59.
Select the correct match:
(1).
G. Mendel – Transformation
(2).
T.H. Morgan – Transduction
(3).
F2 × Recessive parent – Dihybrid cross
(4).
Ribozyme - Nucleic acid

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Solution
Year: 2018
Topic: Molecular Basis of Inheritance
60.
AGGTATCGCAT is a sequence from the coding strand of a gene. What will be the corresponding sequence of the transcribed mRNA?
(1).
UCCAUAGCGUA
(2).
ACCUAUGCGAU
(3).
UGGTUTCGCAT
(4).
AGGUAUCGCAU

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Solution
Year: 2017
Topic: Molecular Basis of Inheritance
61.
Spliceosomes are not found in cells of
(1).
bacteria.
(2).
plants.
(3).
fungi.
(4).
animals.

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Year: 2017
Topic: Molecular Basis of Inheritance
62.
The association of histone H1 with a nucleosome indicates
(1).
the DNA double helix is exposed.
(2).
transcription is occurring.
(3).
DNA replication is occurring.
(4).
the DNA is condensed into a chromatin fibre.

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Year: 2017
Topic: Molecular Basis of Inheritance
63.
Which of the following RNA's is the most abundant in animal cell ?
(1).
mi-RNA
(2).
r-RNA
(3).
t-RNA
(4).
m-RNA

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Solution
Year: 2017
Topic: Molecular Basis of Inheritance
64.
If there are 999 bases in an RNA that codes for a protein with 333 amino acids, and the base at position 901 is deleted such that the length of the RNA becomes 998 bases, how many codons will be altered ?
(1).
333
(2).
1
(3).
11
(4).
33

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Solution
Year: 2017
Topic: Molecular Basis of Inheritance
65.
Thalassemia and sickle cell anaemia are caused due to a problem in globin molecule synthesis. Select the correct statement.
(1).
Sickle cell anemia is due to a quantitative problem of globin molecules. Options
(2).
Both are due to a qualitative defect in globin chain synthesis.
(3).
Both are due to a quantitative defect in globin chain synthesis.
(4).
Thalassemia is due to less synthesis of globin molecules.

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Solution
Year: 2016
Topic: Molecular Basis of Inheritance
66.
Which of the following is required as inducer(s) for the expression of lac operon ?
(1).
galactose
(2).
lactose
(3).
lactose and galactose
(4).
glucose

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Solution
Year: 2016
Topic: Molecular Basis of Inheritance
67.
A complex of ribosomes attached to a single strand of RNA is known as
(1).
polymer
(2).
polypeptide
(3).
okazaki fragment
(4).
polysome

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Solution
Year: 2016
Topic: Molecular Basis of Inheritance
68.
Which one of the following is the start codon ?
(1).
UGA
(2).
UAA
(3).
UAG
(4).
AUG

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